1. Michael Cera

Zach puts Michael Cera, the Superbad and Juno star in the hot seat for this special Comedy Death-Ray interview.

2. Jimmy Kimmel

Zach interviews talk show host Jimmy Kimmel.

3. Jon Hamm

Zach interviews Jon Hamm of AMC's Mad Men.

4. Natalie Portman

Zach interviews Natalie Portman and her dog, Whiz.

5. Bradley Cooper

Zach chats with Bradley Cooper, star of "The Hangover."

6. Charlize Theron

Zach has a chat with Charlize Theron, Academy Award winner and star of The Road.

7. Conan O'Brien & Andy Richter

Zach sits down with the host of the Tonight Show, Conan O'Brien, and his announcer, Andy Richter.

8. Ben Stiller

Zach sits down with Ben Stiller, star of the 'Meet the Fockers' series as well as the new movie, Greenberg.

9. Steve Carell

Zach sits down with Steve Carell from "The Office" and they quite possibly discuss "Dinner for Schmucks".

10. Sean Penn

Sean Penn sits down with Zach's twin brother, Seth Galifianakis.

11. Bruce Willis

Zach sits down with Bruce Willis; one of the stars of the new movie Red, to talk about the 80s and some of the prestigious awards he has been awarded.

12. Jennifer Aniston & Tila Tequila

Zach sits down with Tila Tequila who may become his new best friend and also welcomes another guest on the show who some people may recognize (Jennifer Aniston).

14. Oscar Buzz Edition (1)

Zach Galifianakis sits down with Jennifer Lawrence, Anne Hathaway, Christoph Waltz, Naomi Watts & Amy Adams who are getting all the buzz during this Oscar season.

15. Oscar Buzz Edition (2)

Zach Galifianakis sits down with Bradley Cooper, Jessica Chastain, Sally Field and another special guest from Lincoln.

16. James Franco

Zach Galifianakis sits down with James Franco to have a normal, everyday, run of the mill interview.

17. Justin Bieber

Zach Galifianakis sits down with Justin Bieber for an interview no one will ever forget.

18. President Barack Obama

President Barack Obama sits down with Zach Galifianakis for his most memorable interview yet.

19. Brad Pitt

Brad Pitt sits down with Zach Galifianakis for his second most memorable interview yet.

20. Hillary Clinton

Hillary Clinton sits down with Zach Galifianakis for her most memorable interview yet.

21. Jerry Seinfeld & Cardi B

Jerry Seinfeld and Cardi B sit down with Zach Galifianakis for an interview without coffee, cars, or money moves.