1. Valerie Bertinelli; Catherine Zeta-Jones

Catherine Zeta-Jones joins Drew for the Season 6 premiere to tell her all about the exciting second season of "Wednesday"; Drew covers the headlines with pals Ross Mathews and Valerie Bertinelli.

2. Halle Berry; Kristina Zias

Drew, Halle Berry and Kristina Zias celebrate aging by helping a viewer over 50 achieve a glow-up look.

4. Issa Rae

Issa Rae tells Drew about her new book, "I Should Be Smarter by Now," and upcoming two-part docuseries, "Seen & Heard."

5. Valerie Bertinelli; Pilar Valdes

Valerie Bertinelli joins Drew and Ross Mathews to hit the headlines; Drew tells a special Adam Sandler story in honor of his birthday; Pilar Valdes has some easy advice for a week of meal prepping.

6. Michael and Cameron Douglas

Drew chats with father-son duo Michael and Cameron Douglas.

7. David Letterman

Drew sits down with David Letterman, who plays a round of memory bank and shares his memories of some of his most iconic moments.

8. Sunny Anderson

Sunny Anderson covers the headlines with Drew and Ross and provides suggestions for decluttering your closet and an easy dip recipe.

9. Sunny Anderson; Emeril Lagasse

Sunny Anderson gets a big surprise from Drew: cooking with the legendary Emeril Lagasse!

10. Jennifer Aniston

Drew chats with Jennifer Aniston about the new season of "The Morning Show," her kids cookbook, "Cook With Clydeo," and her hair care line.

175. Natalie Portman, Pilar Valdes

Natalie Portman tells Drew about her animated movie “Arco” and plays balloon BTS revealing tidbits about her biggest film roles. Pilar Valdes shares her latest pro tip from the iconic NYC restaurant Veselka and Ross shares his healthier version of their famous pierogies.